George States, an American is at the last stage of brain cancer and not more than six months to live. He is told that if he extracts blood from the Nagmani of a Nagin, which is a shape shifting Cobra, then he will escape death and be immortal. However, to get the Nagmani he must capture a male snake then the Nagin will follow to rescue him. George hires people to get hold of a male snake and keeps it in a glass box where he tortures it. As expected the female snake comes looking for him.
The nagin turns into a beautiful woman, played by Mallika Sherawat. She helps several women who are helpless and tortured. When she herself is attacked two men who try to rape her, she turns back into a giant Cobra and kills them. They are incidentally the henchmen of George. She turns into a beautiful girl again after her killings. Police inspector Gupta and his wife help Nagin to find a mate but have no idea that the several murders taken place are because of her.
The Nagin reaches George house and finds her captured male snake and they copulate and she gets pregnant. At that very moment George captures the Nagin and kills the male snake to get the Nagmani. Furious and sad over the death of her mate, Nagin kills George by electrocuting him and leaves with the body of her dead mate. She then gives birth to her numerous baby Cobras. The movie is directed by Jennifer Lynch and produced by Govind Menon and Vickram Singh. The music is composed by Anu Malik.